吃瓜tv

Publications

Velasquez Silvia Melina, Fletcher Georgina, Burel Jean鈥怣arie, Parsons Maddy, Swedlow Jason, Hartley Matthew, Bagia Seema, Beckett Alison, Crichton James H, Cross Stephen John, Foulkes Daniel M, Grimshaw James, Held Marie, Ho Kenneth, Jones Martin, Lee Martin, Marcello Marco, Marcotti Stefania, Markus Robert, , Thomas Steven G, West Steven J, Wheeler Ann, K眉pc眉 Yolda艧 Ayb眉ke

Journal of Microscopy (2026)

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British Journal of Pharmacology Vol 183, pp. 760-761 (2026)

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Biomedical Optics Express Vol 17, pp. 769-783 (2026)

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Pharmacology 2025 - Annual Meeting of the British Pharmacological Society (BPS) (2025)

Maslen Charlie, Chattopadhyay Purnesh, K眉hne Marie Theres, ,

Journal of Applied Polymer Science Vol 142 (2025)

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PGI 9th Annual Conference (2025)

Research Interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen.聽Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size.聽We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the 吃瓜tv Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional Activities

Contributor

13/4/2026

Organiser

23/7/2025

Contributor

2/7/2025

Speaker

2/6/2025

Speaker

15/5/2025

Speaker

3/4/2025

Projects

Patton, Brian (Principal Investigator) McConnell, Gail (Co-investigator) Caplan, Holly (Research Co-investigator)

01-Jan-2025 - 01-Jan-2029

McConnell, Gail (Principal Investigator)

23-Jan-2025 - 01-Jan-2025

Eastham, Sarah (Researcher) Wu, Junxi (Co-investigator) McConnell, Gail (Co-investigator) Carswell, Hilary (Co-investigator)

RS MacDonald facility access funding (拢9,500) awarded by SULSA to investigate angiogenesis in the context of ischaemic stroke.

05-Jan-2025 - 04-Jan-2026

McConnell, Gail (Principal Investigator)

05-Jan-2024 - 31-Jan-2024

McConnell, Gail (Principal Investigator)

04-Jan-2024 - 09-Jan-2024

Bauer, Ralf (Principal Investigator) Cunningham, Margaret Rose (Co-investigator) McConnell, Gail (Co-investigator)

01-Jan-2024 - 31-Jan-2025